Title |
Iteration method for predicting essential proteins based on orthology and protein-protein interaction networks
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Published in |
BMC Systems Biology, July 2012
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DOI | 10.1186/1752-0509-6-87 |
Pubmed ID | |
Authors |
Wei Peng, Jianxin Wang, Weiping Wang, Qing Liu, Fang-Xiang Wu, Yi Pan |
Abstract |
Identification of essential proteins plays a significant role in understanding minimal requirements for the cellular survival and development. Many computational methods have been proposed for predicting essential proteins by using the topological features of protein-protein interaction (PPI) networks. However, most of these methods ignored intrinsic biological meaning of proteins. Moreover, PPI data contains many false positives and false negatives. To overcome these limitations, recently many research groups have started to focus on identification of essential proteins by integrating PPI networks with other biological information. However, none of their methods has widely been acknowledged. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Hungary | 1 | 2% |
Netherlands | 1 | 2% |
Germany | 1 | 2% |
Mexico | 1 | 2% |
United Kingdom | 1 | 2% |
Unknown | 45 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 23% |
Researcher | 7 | 13% |
Student > Bachelor | 6 | 12% |
Student > Master | 6 | 12% |
Professor > Associate Professor | 4 | 8% |
Other | 7 | 13% |
Unknown | 10 | 19% |
Readers by discipline | Count | As % |
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Computer Science | 16 | 31% |
Agricultural and Biological Sciences | 13 | 25% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Engineering | 2 | 4% |
Mathematics | 1 | 2% |
Other | 2 | 4% |
Unknown | 11 | 21% |