Title |
MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses
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Published in |
Genome Biology, June 2016
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DOI | 10.1186/s13059-016-0980-6 |
Pubmed ID | |
Authors |
Vanni Bucci, Belinda Tzen, Ning Li, Matt Simmons, Takeshi Tanoue, Elijah Bogart, Luxue Deng, Vladimir Yeliseyev, Mary L. Delaney, Qing Liu, Bernat Olle, Richard R. Stein, Kenya Honda, Lynn Bry, Georg K. Gerber |
Abstract |
Predicting dynamics of host-microbial ecosystems is crucial for the rational design of bacteriotherapies. We present MDSINE, a suite of algorithms for inferring dynamical systems models from microbiome time-series data and predicting temporal behaviors. Using simulated data, we demonstrate that MDSINE significantly outperforms the existing inference method. We then show MDSINE's utility on two new gnotobiotic mice datasets, investigating infection with Clostridium difficile and an immune-modulatory probiotic. Using these datasets, we demonstrate new capabilities, including accurate forecasting of microbial dynamics, prediction of stable sub-communities that inhibit pathogen growth, and identification of bacteria most crucial to community integrity in response to perturbations. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 13 | 35% |
France | 6 | 16% |
United Kingdom | 5 | 14% |
Greece | 1 | 3% |
Netherlands | 1 | 3% |
Unknown | 11 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 17 | 46% |
Members of the public | 17 | 46% |
Science communicators (journalists, bloggers, editors) | 2 | 5% |
Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 1% |
Finland | 1 | <1% |
Japan | 1 | <1% |
India | 1 | <1% |
Unknown | 367 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 101 | 27% |
Researcher | 77 | 21% |
Student > Master | 33 | 9% |
Student > Doctoral Student | 24 | 6% |
Student > Bachelor | 21 | 6% |
Other | 55 | 15% |
Unknown | 63 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 92 | 25% |
Biochemistry, Genetics and Molecular Biology | 58 | 16% |
Immunology and Microbiology | 38 | 10% |
Computer Science | 21 | 6% |
Engineering | 20 | 5% |
Other | 69 | 18% |
Unknown | 76 | 20% |