Title |
Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi
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Published in |
BMC Genomics, January 2009
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DOI | 10.1186/1471-2164-10-36 |
Pubmed ID | |
Authors |
Kathryn E Holt, Nicholas R Thomson, John Wain, Gemma C Langridge, Rumina Hasan, Zulfiqar A Bhutta, Michael A Quail, Halina Norbertczak, Danielle Walker, Mark Simmonds, Brian White, Nathalie Bason, Karen Mungall, Gordon Dougan, Julian Parkhill |
Abstract |
Of the > 2000 serovars of Salmonella enterica subspecies I, most cause self-limiting gastrointestinal disease in a wide range of mammalian hosts. However, S. enterica serovars Typhi and Paratyphi A are restricted to the human host and cause the similar systemic diseases typhoid and paratyphoid fever. Genome sequence similarity between Paratyphi A and Typhi has been attributed to convergent evolution via relatively recent recombination of a quarter of their genomes. The accumulation of pseudogenes is a key feature of these and other host-adapted pathogens, and overlapping pseudogene complements are evident in Paratyphi A and Typhi. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Italy | 1 | <1% |
Netherlands | 1 | <1% |
United Kingdom | 1 | <1% |
Australia | 1 | <1% |
Unknown | 167 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 45 | 26% |
Researcher | 32 | 18% |
Student > Master | 24 | 14% |
Student > Bachelor | 14 | 8% |
Student > Postgraduate | 8 | 5% |
Other | 23 | 13% |
Unknown | 27 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 73 | 42% |
Biochemistry, Genetics and Molecular Biology | 30 | 17% |
Immunology and Microbiology | 11 | 6% |
Medicine and Dentistry | 11 | 6% |
Unspecified | 4 | 2% |
Other | 13 | 8% |
Unknown | 31 | 18% |