Title |
Expression of iron-related genes in human brain and brain tumors
|
---|---|
Published in |
BMC Neuroscience, April 2009
|
DOI | 10.1186/1471-2202-10-36 |
Pubmed ID | |
Authors |
Milla M Hänninen, Joonas Haapasalo, Hannu Haapasalo, Robert E Fleming, Robert S Britton, Bruce R Bacon, Seppo Parkkila |
Abstract |
Defective iron homeostasis may be involved in the development of some diseases within the central nervous system. Although the expression of genes involved in normal iron balance has been intensively studied in other tissues, little is known about their expression in the brain. We investigated the mRNA levels of hepcidin (HAMP), HFE, neogenin (NEO1), transferrin receptor 1 (TFRC), transferrin receptor 2 (TFR2), and hemojuvelin (HFE2) in normal human brain, brain tumors, and astrocytoma cell lines. The specimens included 5 normal brain tissue samples, 4 meningiomas, one medulloblastoma, 3 oligodendrocytic gliomas, 2 oligoastrocytic gliomas, 8 astrocytic gliomas, and 3 astrocytoma cell lines. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Slovakia | 1 | 2% |
Canada | 1 | 2% |
Unknown | 58 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 25% |
Researcher | 9 | 15% |
Student > Master | 7 | 12% |
Student > Doctoral Student | 5 | 8% |
Lecturer | 4 | 7% |
Other | 11 | 18% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 28% |
Biochemistry, Genetics and Molecular Biology | 11 | 18% |
Agricultural and Biological Sciences | 10 | 17% |
Neuroscience | 6 | 10% |
Unspecified | 1 | 2% |
Other | 5 | 8% |
Unknown | 10 | 17% |