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Capillary lactate concentration on admission of normotensive trauma patients: a prospective study

Overview of attention for article published in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, June 2016
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Title
Capillary lactate concentration on admission of normotensive trauma patients: a prospective study
Published in
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, June 2016
DOI 10.1186/s13049-016-0272-x
Pubmed ID
Authors

Pierre Bouzat, Clotilde Schilte, Marc Vinclair, Pauline Manhes, Julien Brun, Jean-Luc Bosson, Jean-François Payen

Abstract

Elevated serum blood lactate is an indicator of on-going bleeding in severe trauma patients. Point-of-care (POC) capillary lactate measurement devices may be useful to rapidly assess lactate concentration at the bedside. The aim of this study was to test the diagnostic performance of capillary lactate to predict significant transfusion in normotensive trauma patients. We conducted a prospective observational study in one level-I trauma centre. From August 2011 to February 2013, 120 consecutive adult patients with systolic blood pressure (SBP) higher than 90 mmHg were included. Capillary lactate was measured on admission in the trauma bay. The primary outcome was defined as a significant transfusion within the first 48 h. Diagnostic performance was determined using receiver operating characteristic (ROC) curve analysis. We also tested the agreement between capillary lactate and blood lactate concentrations using Bland and Altman analysis. Of the 120 normotensive trauma patients, 30 (25 %) required at least one unit of packed red blood cells (RBC) and 12 (10 %) patients received at least four RBC within the first 48 h. All patients with significant RBC transfusion had capillary lactate higher than 3.5 mmol/l. The area under the ROC curve of capillary lactate on admission to predict transfusion of at least 4 RBC units was 0.68 [95 % CI 0.58 - 0.78]. The average bias between capillary and blood lactate measurements was 2.4 mmol/l with a standard deviation of 3.0 mmol/l (n = 60 patients). Although a significant association was found between POC lactate concentration and transfusion requirements, the diagnostic performance of capillary lactate measurements was poor. Due to large disagreement between capillary lactate and blood lactate, capillary lactate cannot be considered in the clinical setting. ClinicalTrials.gov, No. NCT01793428 .

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Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Student > Master 4 13%
Other 3 10%
Student > Postgraduate 3 10%
Student > Doctoral Student 2 7%
Other 5 17%
Unknown 7 23%
Readers by discipline Count As %
Medicine and Dentistry 17 57%
Nursing and Health Professions 1 3%
Decision Sciences 1 3%
Agricultural and Biological Sciences 1 3%
Social Sciences 1 3%
Other 1 3%
Unknown 8 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2016.
All research outputs
#15,377,214
of 22,876,619 outputs
Outputs from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#1,022
of 1,259 outputs
Outputs of similar age
#213,143
of 341,017 outputs
Outputs of similar age from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#31
of 36 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,259 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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