Title |
Stereotactic Ablative Radio Therapy (SABR) followed by immunotherapy a challenge for individualized treatment of metastatic solid tumours
|
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Published in |
Journal of Translational Medicine, May 2012
|
DOI | 10.1186/1479-5876-10-104 |
Pubmed ID | |
Authors |
Giuseppe V Masucci, Peter Wersäll, Rolf Kiessling, Andreas Lundqvist, Rolf Lewensohn |
Abstract |
Combination strategies surely play a crucial role in treatment of cancer. Stereotactic ablative radiotherapy (SABR) has been described to induce abscopal effects particularly in renal cell cancer metastases. This effect is a reaction induced following irradiation of tumour tissue and occurring in another metastatic location outside the treatment field. However, this effect is limited and occurs sparsely in about 1-5% of patient. We are planning to improve the clinical outcome of this treatment in metastatic solid tumours by combining SABR with sequential immunotherapeutic treatments including vaccination strategies, adoptive cell therapy, cytokine therapy, or anti-CTLA-4 therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 8 | 24% |
Student > Master | 5 | 15% |
Researcher | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Student > Ph. D. Student | 3 | 9% |
Other | 7 | 21% |
Unknown | 4 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 41% |
Agricultural and Biological Sciences | 6 | 18% |
Immunology and Microbiology | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 2 | 6% |
Unknown | 7 | 21% |