Title |
Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis
|
---|---|
Published in |
Theoretical Biology and Medical Modelling, June 2016
|
DOI | 10.1186/s12976-016-0042-5 |
Pubmed ID | |
Authors |
Felix Scholkmann |
Abstract |
Coordinated interaction of single cells by cell-to-cell communication (signalling) enables complex behaviour necessary for the functioning of multicellular organisms. A quite newly discovered cell-to-cell signalling mechanism relies on nanotubular cell-co-cell connections, termed "membrane nanotubes" (MNTs). The present paper presents the hypothesis that mitochondria inside MNTs can form a connected structure (mitochondrial network) which enables the exchange of energy and signals between cells. It is proposed that two modes of energy and signal transmission may occur: electrical/electrochemical and electromagnetic (optical). Experimental work supporting the hypothesis is reviewed, and suggestions for future research regarding the discussed topic are given. |
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