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Coronary flow velocity reserve by echocardiography: feasibility, reproducibility and agreement with PET in overweight and obese patients with stable and revascularized coronary artery disease

Overview of attention for article published in Cardiovascular Ultrasound, June 2016
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Title
Coronary flow velocity reserve by echocardiography: feasibility, reproducibility and agreement with PET in overweight and obese patients with stable and revascularized coronary artery disease
Published in
Cardiovascular Ultrasound, June 2016
DOI 10.1186/s12947-016-0066-3
Pubmed ID
Authors

Rasmus Huan Olsen, Lene Rørholm Pedersen, Martin Snoer, Thomas Emil Christensen, Adam Ali Ghotbi, Philip Hasbak, Andreas Kjaer, Steen B. Haugaard, Eva Prescott

Abstract

Coronary flow velocity reserve (CFVR) measured by transthoracic Doppler echocardiography of the LAD is used to assess microvascular function but validation studies in clinical settings are lacking. We aimed to assess feasibility, reproducibility and agreement with myocardial flow reserve (MFR) measured by PET in overweight and obese patients. Participants with revascularized coronary artery disease were examined by CFVR. Subgroups were examined by repeated CFVR (reproducibility) or Rubidium-82-PET (agreement). To account for time variation, results were computed for scans performed within a week (1-week) and for all scans regardless of time gap (total) and to account for scar tissue for patients with and without previous myocardial infarction (MI). Eighty-six patients with median BMI 30.9 (IQR 29.4-32.9) kg × m(-2) and CFVR 2.29 (1.90-2.63) were included. CFVR was feasible in 83 (97 %) using a contrast agent in 14 %. For reproducibility overall (n = 21) limits of agreement (LOA) were (-0.75;0.71), within-subjects coefficient of variation (CV) 11 %, and reliability 0.84. For reproducibility within 1-week (n = 13) LOA were (-0.33;0.25), within-subjects CV 5 %, and reliability 0.97. Agreement with MFR of the LAD territory (n = 35) was without significant bias and overall LOA were (-1.40;1.46). Agreement was best for examinations performed within 1-week of participants without MI of the LAD-territory (n = 12); LOA = (-0.68;0.88). CFVR was highly feasible with a good reproducibility on par with other contemporary measures applied in cardiology. Agreement with MFR was acceptable, though discrepancy related to prior MI has to be considered. CFVR of LAD is a valid tool in overweight and obese patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 17%
Researcher 9 16%
Student > Bachelor 5 9%
Student > Master 4 7%
Student > Doctoral Student 2 3%
Other 8 14%
Unknown 20 34%
Readers by discipline Count As %
Medicine and Dentistry 24 41%
Agricultural and Biological Sciences 3 5%
Engineering 3 5%
Biochemistry, Genetics and Molecular Biology 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 7%
Unknown 22 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2016.
All research outputs
#17,807,987
of 22,876,619 outputs
Outputs from Cardiovascular Ultrasound
#229
of 310 outputs
Outputs of similar age
#241,949
of 341,017 outputs
Outputs of similar age from Cardiovascular Ultrasound
#5
of 6 outputs
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So far Altmetric has tracked 310 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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