Title |
Perioperative bridging anticoagulation for atrial fibrillation—the first randomised controlled trial
|
---|---|
Published in |
Perioperative Medicine, June 2016
|
DOI | 10.1186/s13741-016-0040-5 |
Pubmed ID | |
Authors |
James Matthew Wight, Malachy Oliver Columb |
Abstract |
Patients who have atrial fibrillation (AF) have increased thromboembolic risk. This risk is mitigated through use of anticoagulants, traditionally with vitamin K antagonists such as warfarin, and more recently with drugs such as Xa and thrombin inhibitors. Since anticoagulants increase the risk of bleeding, uncertainty exists regarding their use in the perioperative period. The risk of thromboembolism for each patient must be balanced against risk of bleeding; anticoagulation medication may be continued, replaced with a short-acting alternative or withheld entirely. Until recently, evidence on best management relied on expert opinion and observational studies. The recent publication of a randomised, double-blind, placebo-controlled trial (BRIDGE) has added important information to the knowledge base. BRIDGE ClinicalTrials.gov, NCT00786474. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 16% |
Researcher | 4 | 13% |
Student > Ph. D. Student | 3 | 10% |
Lecturer | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 7 | 23% |
Unknown | 8 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 45% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 13% |
Economics, Econometrics and Finance | 2 | 6% |
Agricultural and Biological Sciences | 1 | 3% |
Unknown | 10 | 32% |