Title |
Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex
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Published in |
BMC Neuroscience, July 2012
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DOI | 10.1186/1471-2202-13-87 |
Pubmed ID | |
Authors |
Leonora E Long, Jonna Lind, Maree Webster, Cynthia Shannon Weickert |
Abstract |
Endocannabinoids provide control over cortical neurotransmission. We investigated the developmental expression of key genes in the endocannabinoid system across human postnatal life and determined whether they correspond to the development of markers for inhibitory interneurons, which shape cortical development. We used microarray with qPCR validation and in situ hybridisation to quantify mRNA for the central endocannabinoid receptor CB(1)R, endocannabinoid synthetic enzymes (DAGLα for 2-arachidonylglycerol [2-AG] and NAPE-PLD for anandamide), and inactivating enzymes (MGL and ABHD6 for 2-AG and FAAH for anandamide) in human dorsolateral prefrontal cortex (39 days - 49 years). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Spain | 1 | 33% |
Mexico | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 3% |
Portugal | 1 | <1% |
Australia | 1 | <1% |
Unknown | 113 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 24 | 20% |
Student > Bachelor | 20 | 17% |
Researcher | 17 | 14% |
Student > Master | 10 | 8% |
Professor > Associate Professor | 9 | 8% |
Other | 22 | 19% |
Unknown | 16 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 20 | 17% |
Neuroscience | 17 | 14% |
Medicine and Dentistry | 15 | 13% |
Psychology | 15 | 13% |
Biochemistry, Genetics and Molecular Biology | 6 | 5% |
Other | 16 | 14% |
Unknown | 29 | 25% |