Title |
Surgical and molecular pathology of pancreatic neoplasms
|
---|---|
Published in |
Diagnostic Pathology, June 2016
|
DOI | 10.1186/s13000-016-0497-z |
Pubmed ID | |
Authors |
Wenzel M. Hackeng, Ralph H. Hruban, G. Johan A. Offerhaus, Lodewijk A. A. Brosens |
Abstract |
Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment. This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 25% |
France | 1 | 25% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 162 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 26 | 16% |
Student > Master | 21 | 13% |
Student > Ph. D. Student | 18 | 11% |
Researcher | 17 | 10% |
Other | 15 | 9% |
Other | 31 | 19% |
Unknown | 34 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 66 | 41% |
Biochemistry, Genetics and Molecular Biology | 28 | 17% |
Agricultural and Biological Sciences | 8 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Engineering | 3 | 2% |
Other | 11 | 7% |
Unknown | 40 | 25% |