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X Demographics
Mendeley readers
| Title |
Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy
|
|---|---|
| Published in |
Infectious Diseases of Poverty, June 2016
|
| DOI | 10.1186/s40249-016-0140-y |
| Pubmed ID | |
| Authors |
Liesbeth Mieras, Richard Anthony, Wim van Brakel, Martin W. Bratschi, Jacques van den Broek, Emmanuelle Cambau, Arielle Cavaliero, Christa Kasang, Geethal Perera, Lee Reichman, Jan Hendrik Richardus, Paul Saunderson, Peter Steinmann, Wing Wai Yew |
| Abstract |
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among contacts by around 60 % in the first 2-3 years after receiving SDR. In countries where SDR is currently being implemented under routine programme conditions in defined areas, questions were raised by health authorities and professional bodies about the possible risk of inducing rifampicin resistance among the M. tuberculosis strains circulating in these areas. This issue has not been addressed in scientific literature to date. To produce an authoritative consensus statement about the risk that SDR would induce rifampicin-resistant tuberculosis, a meeting was convened with tuberculosis (TB) and leprosy experts. The experts carefully reviewed and discussed the available evidence regarding the mechanisms and risk factors for the development of (multi) drug-resistance in M. tuberculosis with a view to the special situation of the use of SDR as PEP for leprosy. They concluded that SDR given to contacts of leprosy patients, in the absence of symptoms of active TB, poses a negligible risk of generating resistance in M. tuberculosis in individuals and at the population level. Thus, the benefits of SDR prophylaxis in reducing the risk of developing leprosy in contacts of new leprosy patients far outweigh the risks of generating drug resistance in M. tuberculosis. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 115 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 16% |
| Student > Master | 17 | 15% |
| Other | 10 | 9% |
| Student > Bachelor | 7 | 6% |
| Student > Postgraduate | 5 | 4% |
| Other | 16 | 14% |
| Unknown | 43 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 33% |
| Nursing and Health Professions | 9 | 8% |
| Immunology and Microbiology | 6 | 5% |
| Social Sciences | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Other | 6 | 5% |
| Unknown | 47 | 41% |