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Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines

Overview of attention for article published in BMC Veterinary Research, July 2012
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Title
Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
Published in
BMC Veterinary Research, July 2012
DOI 10.1186/1746-6148-8-128
Pubmed ID
Authors

Atsuko Murai, Samah Abou Asa, Atsushi Kodama, Akihiro Hirata, Tokuma Yanai, Hiroki Sakai

Abstract

Canine hemangiosarcoma (HSA) is a malignant tumor with poor long-term prognosis due to development of metastasis despite aggressive treatment. The phosphatidyl-inositol-3 kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is involved in its endothelial pathologies; however, it remains unknown how this pathway plays a role in canine HSA. Here, we characterized new canine HSA cell lines derived from nude mice-xenografted canine HSAs and investigated the deregulation of the signaling pathways in these cell lines.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Unknown 69 97%

Demographic breakdown

Readers by professional status Count As %
Other 11 15%
Researcher 11 15%
Student > Doctoral Student 9 13%
Student > Postgraduate 8 11%
Student > Ph. D. Student 5 7%
Other 11 15%
Unknown 16 23%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 29 41%
Medicine and Dentistry 15 21%
Biochemistry, Genetics and Molecular Biology 6 8%
Agricultural and Biological Sciences 4 6%
Linguistics 1 1%
Other 1 1%
Unknown 15 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2012.
All research outputs
#14,148,857
of 22,673,450 outputs
Outputs from BMC Veterinary Research
#1,102
of 3,031 outputs
Outputs of similar age
#96,147
of 164,749 outputs
Outputs of similar age from BMC Veterinary Research
#18
of 35 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,031 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,749 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.