Title |
Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker
|
---|---|
Published in |
Journal of Translational Medicine, July 2012
|
DOI | 10.1186/1479-5876-10-140 |
Pubmed ID | |
Authors |
Efstathios Vassiliadis, Lars M Rasmussen, Inger Byrjalsen, Dorthe Vang Larsen, Rajiv Chaturvedi, Susanne Hosbond, Lotte Saabye, Axel CP Diederichsen, Federica Genovese, Kevin L Duffin, Qinlong Zheng, Xiaoliang Chen, Diana J Leeming, Claus Christiansen, Morten A Karsdal |
Abstract |
Titin is a muscle-specific protein found in cardiac and skeletal muscles which is responsible for restoring passive tension. Levels and functioning of titin have been shown to be affected by cardiac damage. Due to the inherent difficulty of measuring titin levels in vivo in a clinical setting, we aimed to develop an assay that could reliably measure fragments of degraded titin in serum and potentially be used in the assessment of cardiac muscle damage. |
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