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Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony

Overview of attention for article published in Echo Research & Practice, June 2016
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Title
Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony
Published in
Echo Research & Practice, June 2016
DOI 10.1530/erp-16-0011
Pubmed ID
Authors

Ingeborg H. F. Herold, Salvatore Saporito, Massimo Mischi, Hans C. van Assen, R. Arthur Bouwman, Anouk G. W. de Lepper, Harrie C. M. van den Bosch, Hendrikus H. M. Korsten, Patrick Houthuizen

Abstract

Background Pulmonary transit time (PTT) is an indirect measure of preload and left ventricular function, which can be estimated using the indicator dilution theory by contrast-enhanced ultrasound (CEUS). In this study, we first assessed the accuracy of PTT-CEUS by comparing it with dynamic contrast-enhanced MRI (DCE-MRI). Secondly, we tested the hypothesis that PTT-CEUS correlates with the severity of heart failure, assessed by MRI and NT-proBNP. Methods and Results Twenty patients referred to our hospital for cardiac resynchronization therapy (CRT) were enrolled. DCE-MRI, CEUS, and NT-proBNP measurements were performed within an hour. Mean transit time (MTT) was obtained by estimating the time evolution of indicator concentration within regions of interest drawn in the right and left ventricle in videoloops of DCE-MRI and CEUS. PTT was estimated as the difference of the left and right ventricular MTT. Normalized PTT (nPTT) was obtained by multiplication of PTT with the heart rate. Mean PTT-CEUS was 10.5±2.4 s and PTT-DCE-MRI 10.4±2.0 s (P < 0.88). The correlations of PTT and nPTT by CEUS and DCE-MRI were strong; r=0.75 (P < 0.0001) and r=0.76 (P = 0.0001), respectively. Bland Altman analysis revealed a bias of 0.1 s for PTT. nPTT-CEUS correlated moderately with left ventricle volumes. PTT-CEUS and nPTT-CEUS correlated moderate to strong with NT-proBNP; r=0.54 (P = 0.022) and r=0.68 (P = 0.002), respectively. Conclusions (n)PTT-CEUS shows strong agreement with that by DCE-MRI. Given the good correlation with NT-proBNP level, (n)PTT-CEUS may provide a novel, clinically feasible measure to quantify the severity of heart failure.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 18%
Other 4 14%
Researcher 4 14%
Student > Bachelor 2 7%
Student > Master 2 7%
Other 3 11%
Unknown 8 29%
Readers by discipline Count As %
Medicine and Dentistry 12 43%
Engineering 3 11%
Veterinary Science and Veterinary Medicine 2 7%
Economics, Econometrics and Finance 1 4%
Unknown 10 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2016.
All research outputs
#14,390,979
of 25,377,790 outputs
Outputs from Echo Research & Practice
#191
of 268 outputs
Outputs of similar age
#176,573
of 353,657 outputs
Outputs of similar age from Echo Research & Practice
#7
of 9 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 268 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.3. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,657 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.