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Impaired P2Y12 inhibition by clopidogrel in kidney transplant recipients: results from a cohort study

Overview of attention for article published in BMC Nephrology, June 2016
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Title
Impaired P2Y12 inhibition by clopidogrel in kidney transplant recipients: results from a cohort study
Published in
BMC Nephrology, June 2016
DOI 10.1186/s12882-016-0270-2
Pubmed ID
Authors

Clotilde Muller, Nathan Messas, Peggy Perrin, Jerome Olagne, Gabriela Gautier-Vargas, Noelle Cognard, Sophie Caillard, Bruno Moulin, Olivier Morel

Abstract

Cardiovascular complications represent a major cause of morbidity and mortality for patients who received kidney transplantation (KT). However, the impact of KT and chronic immunosuppression on platelet response to clopidogrel in patients undergoing coronary or peripheral revascularization procedures remains unclear. This cohort study compares platelet responsiveness to clopidogrel as assessed byvasodilator-stimulated phosphoprotein (VASP) phosphorylation. The study population was divided between chronic kidney disease (CKD) patients who underwent KT (n = 36) and non-transplanted CKD patients (control group, n = 126). Patients were on maintenance antiplatelet therapy with clopidogrel 75 mg daily for at least 8 days. The mean platelet reactivity index (PRI) VASP values and the prevalence of high on-treatment platelet reactivity (HPR, defined as PRI VASP ≥61 %) were compared. The mean PRI VASP value was significantly higher in the transplant group (60.1 ± 3 vs 51.2 ± 1.6 %; p=0.014). HPR was significantly more common in the transplant group on clopidogrel maintenance therapy (58 vs. 31 %; p = 0.011). KT was the only independent predictor of HPR (odds ratio: 2.6; 95 % confidence interval: 1.03-6.27, p = 0.03). The effect of treatment with calcineurin inhibitors on clopidogrel response could not be analyzed separately from the kidney transplant status. KT is associated with an increased prevalence of HPR. Our results suggest that plateletfunction tests may be clinically useful for the management of this specific population.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 25%
Student > Bachelor 2 17%
Other 1 8%
Student > Doctoral Student 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 3 25%
Readers by discipline Count As %
Medicine and Dentistry 5 42%
Psychology 1 8%
Mathematics 1 8%
Unknown 5 42%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2016.
All research outputs
#5,977,191
of 7,881,477 outputs
Outputs from BMC Nephrology
#664
of 916 outputs
Outputs of similar age
#187,301
of 267,965 outputs
Outputs of similar age from BMC Nephrology
#28
of 36 outputs
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