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A yeast expression system for functional and pharmacological studies of the malaria parasite Ca2+/H+ antiporter

Overview of attention for article published in Malaria Journal, August 2012
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2 X users

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Title
A yeast expression system for functional and pharmacological studies of the malaria parasite Ca2+/H+ antiporter
Published in
Malaria Journal, August 2012
DOI 10.1186/1475-2875-11-254
Pubmed ID
Authors

J Enrique Salcedo-Sora, Steve A Ward, Giancarlo A Biagini

Abstract

Calcium (Ca²⁺) signalling is fundamental for host cell invasion, motility, in vivo synchronicity and sexual differentiation of the malaria parasite. Consequently, cytoplasmic free Ca²⁺ is tightly regulated through the co-ordinated action of primary and secondary Ca²⁺ transporters. Identifying selective inhibitors of Ca²⁺ transporters is key towards understanding their physiological role as well as having therapeutic potential, therefore screening systems to facilitate the search for potential inhibitors are a priority. Here, the methodology for the expression of a Calcium membrane transporter that can be scaled to high throughputs in yeast is presented.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 4%
Slovenia 1 4%
Unknown 24 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 27%
Student > Master 5 19%
Student > Ph. D. Student 4 15%
Student > Postgraduate 2 8%
Student > Bachelor 2 8%
Other 3 12%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 38%
Biochemistry, Genetics and Molecular Biology 5 19%
Chemistry 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Economics, Econometrics and Finance 1 4%
Other 3 12%
Unknown 4 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2012.
All research outputs
#14,604,147
of 22,673,450 outputs
Outputs from Malaria Journal
#4,180
of 5,540 outputs
Outputs of similar age
#100,022
of 164,709 outputs
Outputs of similar age from Malaria Journal
#60
of 85 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,540 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,709 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.