Title |
Translational regulation of Anopheles gambiae mRNAs in the midgut during Plasmodium falciparum infection
|
---|---|
Published in |
BMC Genomics, August 2012
|
DOI | 10.1186/1471-2164-13-366 |
Pubmed ID | |
Authors |
Edward A Mead, Meng Li, Zhijian Tu, Jinsong Zhu |
Abstract |
Malaria is caused by Plasmodium parasites, which are transmitted via the bites of infected Anopheline mosquitoes. Midgut invasion is a major bottleneck for Plasmodium development inside the mosquito vectors. Malaria parasites in the midgut are surrounded by a hostile environment rich in digestive enzymes, while a rapidly responding immune system recognizes Plasmodium ookinetes and recruits killing factors from the midgut and surrounding tissues, dramatically reducing the population of invading ookinetes before they can successfully traverse the midgut epithelium. Understanding molecular details of the parasite-vector interactions requires precise measurement of nascent protein synthesis in the mosquito during Plasmodium infection. Current expression profiling primarily monitors alterations in steady-state levels of mRNA, but does not address the equally critical issue of whether the proteins encoded by the mRNAs are actually synthesized. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Australia | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 67 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 25% |
Student > Ph. D. Student | 12 | 17% |
Student > Master | 12 | 17% |
Student > Postgraduate | 3 | 4% |
Professor > Associate Professor | 3 | 4% |
Other | 8 | 12% |
Unknown | 14 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 33 | 48% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Medicine and Dentistry | 4 | 6% |
Immunology and Microbiology | 3 | 4% |
Computer Science | 2 | 3% |
Other | 2 | 3% |
Unknown | 18 | 26% |