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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis
|
|---|---|
| Published in |
Cell Communication and Signaling, August 2020
|
| DOI | 10.1186/s12964-020-00623-9 |
| Pubmed ID | |
| Authors |
Amir B. Ghaemmaghami, Maryam Mahjoubin-Tehran, Ahmad Movahedpour, Korosh Morshedi, Amirhossein Sheida, Seyed Pouya Taghavi, Hamed Mirzaei, Michael R. Hamblin |
| Abstract |
Malignant gliomas are the most common and deadly type of central nervous system tumors. Despite some advances in treatment, the mean survival time remains only about 1.25 years. Even after surgery, radiotherapy and chemotherapy, gliomas still have a poor prognosis. Exosomes are the most common type of extracellular vesicles with a size range of 30 to 100 nm, and can act as carriers of proteins, RNAs, and other bioactive molecules. Exosomes play a key role in tumorigenesis and resistance to chemotherapy or radiation. Recent evidence has shown that exosomal microRNAs (miRNAs) can be detected in the extracellular microenvironment, and can also be transferred from cell to cell via exosome secretion and uptake. Therefore, many recent studies have focused on exosomal miRNAs as important cellular regulators in various physiological and pathological conditions. A variety of exosomal miRNAs have been implicated in the initiation and progression of gliomas, by activating and/or inhibiting different signaling pathways. Exosomal miRNAs could be used as therapeutic agents to modulate different biological processes in gliomas. Exosomal miRNAs derived from mesenchymal stem cells could also be used for glioma treatment. The present review summarizes the exosomal miRNAs that have been implicated in the pathogenesis, diagnosis and treatment of gliomas. Moreover, exosomal proteins could also be involved in glioma pathogenesis. Exosomal miRNAs and proteins could also serve as non-invasive biomarkers for prognosis and disease monitoring. Video Abstract. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 11% |
| Ireland | 1 | 11% |
| Unknown | 7 | 78% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 14% |
| Researcher | 9 | 11% |
| Student > Doctoral Student | 5 | 6% |
| Student > Ph. D. Student | 5 | 6% |
| Student > Master | 3 | 4% |
| Other | 5 | 6% |
| Unknown | 41 | 52% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Medicine and Dentistry | 10 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Engineering | 4 | 5% |
| Agricultural and Biological Sciences | 3 | 4% |
| Other | 4 | 5% |
| Unknown | 43 | 54% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2023.
All research outputs
#6,956,766
of 25,163,621 outputs
Outputs from Cell Communication and Signaling
#187
of 1,398 outputs
Outputs of similar age
#139,661
of 405,400 outputs
Outputs of similar age from Cell Communication and Signaling
#11
of 55 outputs
Altmetric has tracked 25,163,621 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,398 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.