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Bovine coronavirus in naturally and experimentally exposed calves; viral shedding and the potential for transmission

Overview of attention for article published in Virology Journal, June 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

Mentioned by

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18 tweeters

Citations

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41 Dimensions

Readers on

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83 Mendeley
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Title
Bovine coronavirus in naturally and experimentally exposed calves; viral shedding and the potential for transmission
Published in
Virology Journal, June 2016
DOI 10.1186/s12985-016-0555-x
Pubmed ID
Authors

Veslemøy Sunniva Oma, Madeleine Tråvén, Stefan Alenius, Mette Myrmel, Maria Stokstad

Abstract

Bovine coronavirus (BCoV) is a widely distributed pathogen, causing disease and economic losses in the cattle industry worldwide. Prevention of virus spread is impeded by a lack of basic knowledge concerning viral shedding and transmission potential in individual animals. The aims of the study were to investigate the duration and quantity of BCoV shedding in feces and nasal secretions related to clinical signs, the presence of virus in blood and tissues and to test the hypothesis that seropositive calves are not infectious to naïve in-contact calves three weeks after BCoV infection. A live animal experiment was conducted, with direct contact between animal groups for 24 h as challenge procedure. Four naïve calves were commingled with a group of six naturally infected calves and sequentially euthanized. Two naïve sentinel calves were commingled with the experimentally exposed group three weeks after exposure. Nasal swabs, feces, blood and tissue samples were analyzed for viral RNA by RT-qPCR, and virus isolation was performed on nasal swabs. Serum was analyzed for BCoV antibodies. The calves showed mild general signs, and the most prominent signs were from the respiratory system. The overall clinical score corresponded well with the shedding of viral RNA the first three weeks after challenge. General depression and cough were the signs that correlated best with shedding of BCoV RNA, while peak respiratory rate and peak rectal temperature appeared more than a week later than the peak shedding. Nasal shedding preceded fecal shedding, and the calves had detectable amounts of viral RNA intermittently in feces through day 35 and in nasal secretions through day 28, however virus isolation was unsuccessful from day six and day 18 from the two calves investigated. Viral RNA was not detected in blood, but was found in lymphatic tissue through day 42 after challenge. Although the calves were shedding BCoV RNA 21 days after infection the sentinel animals were not infected. Prolonged shedding of BCoV RNA can occur, but detection of viral RNA does not necessarily indicate a transmission potential. The study provides valuable information with regard to producing scientifically based biosecurity advices.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Norway 1 1%
Unknown 82 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 16%
Student > Master 12 14%
Student > Ph. D. Student 10 12%
Student > Bachelor 8 10%
Other 7 8%
Other 17 20%
Unknown 16 19%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 19 23%
Agricultural and Biological Sciences 18 22%
Medicine and Dentistry 7 8%
Immunology and Microbiology 5 6%
Biochemistry, Genetics and Molecular Biology 5 6%
Other 15 18%
Unknown 14 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2022.
All research outputs
#2,412,192
of 21,200,930 outputs
Outputs from Virology Journal
#212
of 2,893 outputs
Outputs of similar age
#40,506
of 280,965 outputs
Outputs of similar age from Virology Journal
#1
of 1 outputs
Altmetric has tracked 21,200,930 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,893 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,965 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them