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Mendeley readers
Attention Score in Context
| Title |
IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse
|
|---|---|
| Published in |
Skeletal Muscle, July 2012
|
| DOI | 10.1186/2044-5040-2-14 |
| Pubmed ID | |
| Authors |
James P White, Melissa J Puppa, Shuichi Sato, Song Gao, Robert L Price, John W Baynes, Matthew C Kostek, Lydia E Matesic, James A Carson |
| Abstract |
Muscle protein turnover regulation during cancer cachexia is being rapidly defined, and skeletal muscle mitochondria function appears coupled to processes regulating muscle wasting. Skeletal muscle oxidative capacity and the expression of proteins regulating mitochondrial biogenesis and dynamics are disrupted in severely cachectic ApcMin/+ mice. It has not been determined if these changes occur at the onset of cachexia and are necessary for the progression of muscle wasting. Exercise and anti-cytokine therapies have proven effective in preventing cachexia development in tumor bearing mice, while their effect on mitochondrial content, biogenesis and dynamics is not well understood. The purposes of this study were to 1) determine IL-6 regulation on mitochondrial remodeling/dysfunction during the progression of cancer cachexia and 2) to determine if exercise training can attenuate mitochondrial dysfunction and the induction of proteolytic pathways during IL-6 induced cancer cachexia. |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Portugal | 1 | <1% |
| Unknown | 139 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 21% |
| Researcher | 20 | 14% |
| Student > Master | 17 | 12% |
| Student > Bachelor | 14 | 10% |
| Student > Doctoral Student | 9 | 6% |
| Other | 29 | 20% |
| Unknown | 23 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 24% |
| Biochemistry, Genetics and Molecular Biology | 33 | 23% |
| Medicine and Dentistry | 21 | 15% |
| Sports and Recreations | 6 | 4% |
| Chemistry | 6 | 4% |
| Other | 11 | 8% |
| Unknown | 31 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2012.
All research outputs
#4,667,320
of 22,673,450 outputs
Outputs from Skeletal Muscle
#139
of 360 outputs
Outputs of similar age
#32,589
of 164,302 outputs
Outputs of similar age from Skeletal Muscle
#1
of 4 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 360 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,302 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them