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Monitoring of liver function in a 73-year old patient undergoing ‘Associating Liver Partition and Portal vein ligation for Staged hepatectomy’: case report applying the novel liver maximum function…

Overview of attention for article published in Patient Safety in Surgery, June 2016
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Title
Monitoring of liver function in a 73-year old patient undergoing ‘Associating Liver Partition and Portal vein ligation for Staged hepatectomy’: case report applying the novel liver maximum function capacity test
Published in
Patient Safety in Surgery, June 2016
DOI 10.1186/s13037-016-0104-y
Pubmed ID
Authors

Felix Oldhafer, Kristina I. Ringe, Kai Timrott, Moritz Kleine, Wolf Ramackers, Sebastian Cammann, Mark D. Jäger, Juergen Klempnauer, Hueseyin Bektas, Florian W. R. Vondran

Abstract

The two-stage liver resection combining in situ liver transection with portal vein ligation, also referred to as ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy), has been described as a promising method to increase the resectability of liver tumors. However, one of the most important issues regarding the safety of this procedure is the optimal timing of the second stage at the point of sufficient hypertrophy of the future liver remnant. The recently developed liver maximum function capacity test (LiMAx) can be applied to monitor the liver function postoperatively and hence could be a useful tool for decision-making regarding the timing of the second stage of ALPPS. A 73-year-old female patient presented with metachronous colorectal liver metastasis comprising the complete right liver lobe as well as segment IV. Due to an insufficient future liver remnant (19.3 %; segments II and III of the liver) and a low future liver remnant:body weight ratio (0.28 %) the decision was made to perform an ALPPS-procedure in order to avoid development of postoperative small-for-size syndrome. Despite a formally sufficient increase of the FLR to 30.8 % within 7 days after the first step of ALPPS, the liver function was seen to only slowly increase as expressed by a LiMAx value of 245 μg/h/kg (baseline of 282 μg/h/kg prior to surgery). By means of the LiMAx test, sufficient increase of liver function eventually was detected by postoperative day 11 (LiMAx value of 371 μg/h/kg; FLR 35.2 %) so that the second step of ALPPS (completion of hepatectomy) was performed with no signs of liver failure during further clinical course. Performing ALPPS we have observed a significant difference between the increase in future liver remnant volume and function applying the LiMAx test. The latter tool thus might proof valuable for application in two-stage liver resection to avoid postoperative small-for-size syndrome.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 37%
Other 2 11%
Student > Ph. D. Student 2 11%
Student > Doctoral Student 1 5%
Student > Bachelor 1 5%
Other 2 11%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 9 47%
Agricultural and Biological Sciences 1 5%
Nursing and Health Professions 1 5%
Economics, Econometrics and Finance 1 5%
Engineering 1 5%
Other 0 0%
Unknown 6 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2016.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Patient Safety in Surgery
#234
of 253 outputs
Outputs of similar age
#315,800
of 360,136 outputs
Outputs of similar age from Patient Safety in Surgery
#2
of 2 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 253 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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