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Debate: The slippery slope of surrogate outcomes

Overview of attention for article published in Trials, October 2000
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)

Mentioned by

1 blog
4 X users
1 YouTube creator


37 Dimensions

Readers on

28 Mendeley
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Debate: The slippery slope of surrogate outcomes
Published in
Trials, October 2000
DOI 10.1186/cvm-1-2-076
Pubmed ID

Ralph B D'Agostino


Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes. Two recent clinical trials (Heart and Estrogen/Progestin Replacement Study [HERS], and the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [ALLHAT]) underscore this problem since their results contradicted what was expected based on the surrogate outcomes. The current regulatory policy to allow new therapies to be introduced onto the market based solely on surrogate outcomes may need to be reviewed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Colombia 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 18%
Professor 3 11%
Student > Bachelor 3 11%
Student > Postgraduate 3 11%
Student > Ph. D. Student 3 11%
Other 7 25%
Unknown 4 14%
Readers by discipline Count As %
Medicine and Dentistry 12 43%
Biochemistry, Genetics and Molecular Biology 2 7%
Environmental Science 1 4%
Agricultural and Biological Sciences 1 4%
Chemical Engineering 1 4%
Other 4 14%
Unknown 7 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2020.
All research outputs
of 22,673,450 outputs
Outputs from Trials
of 5,819 outputs
Outputs of similar age
of 37,785 outputs
Outputs of similar age from Trials
of 1 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,819 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 37,785 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them