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Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, June 2016
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  • Good Attention Score compared to outputs of the same age (68th percentile)

Mentioned by

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3 tweeters
wikipedia
1 Wikipedia page

Citations

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10 Dimensions

Readers on

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20 Mendeley
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Title
Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma
Published in
Journal of Experimental & Clinical Cancer Research, June 2016
DOI 10.1186/s13046-016-0355-6
Pubmed ID
Authors

Wei Gao, John Zeng-Hong Li, Si-Qi Chen, Chiao-Yun Chu, Jimmy Yu-Wai Chan, Thian-Sze Wong

Abstract

Brain-expressed X-linked (BEX) 4 is a member of BEX family. The functional role of BEX4 in oral squamous cell carcinoma (OSCC) remains unknown. Expression level of BEX family members (BEX1-5) in OSCC tissues and the paired normal epithelial were examined. Functions of epigenetic changes (DNA methylation and histone modifications) on BEX4 suppression in OSCC were examined by zebularine and trichostatin A (TSA) treatment on OSCC cell lines. Lentivector containing full-length BEX4 was used to generate OSCC cell lines with stable BEX4 expression. Effects of BEX4 expression on OSCC proliferation were monitored with xCELLigence RTCA real-time cell analyzer. BEX4-overexpressing CAL27 was implanted into nude mice to evaluate the effects on tumor growth in vivo. The signaling pathways regulated by BEX4 in OSCC was explored using human whole-transcript expression microarray. Among the 5 BEX family members, BEX1 and BEX4 showed significant down-regulation in OSCC (P < 0.001). BEX3, in comparison, was overexpressed in the primary tumor. BEX4 expression in OSCC cell lines was re-activated after zebularine and TSA treatment. High BEX4 expression could suppress proliferation of OSCC in vitro. Subcutaneous tumor volume of BEX4-overexpressing CAL27 was remarkably reduced in nude mice. Microarray experiment showed that S100A family members (S100A7, S100A7A, S100A8, S100A9 & S100A12) might be the downstream targets of BEX4 in OSCC. BEX4 functions as tumor suppressor by inhibiting proliferation and growth of oral cancer. Decreased BEX4 contributes to the increased proliferative propensity of OSCC.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Slovenia 1 5%
Unknown 18 90%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 25%
Researcher 5 25%
Student > Master 4 20%
Student > Ph. D. Student 2 10%
Other 1 5%
Other 3 15%
Readers by discipline Count As %
Medicine and Dentistry 9 45%
Biochemistry, Genetics and Molecular Biology 4 20%
Agricultural and Biological Sciences 2 10%
Immunology and Microbiology 1 5%
Neuroscience 1 5%
Other 0 0%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2022.
All research outputs
#6,335,729
of 21,446,675 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#292
of 1,906 outputs
Outputs of similar age
#88,592
of 280,922 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#1
of 1 outputs
Altmetric has tracked 21,446,675 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,906 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,922 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them