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Aprepitant versus ondansetron in preoperative triple-therapy treatment of nausea and vomiting in neurosurgery patients: study protocol for a randomized controlled trial

Overview of attention for article published in Trials, August 2012
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Title
Aprepitant versus ondansetron in preoperative triple-therapy treatment of nausea and vomiting in neurosurgery patients: study protocol for a randomized controlled trial
Published in
Trials, August 2012
DOI 10.1186/1745-6215-13-130
Pubmed ID
Authors

Sergio Bergese, Adolfo Viloria, Alberto Uribe, Alejandra Antor, Soledad Fernandez

Abstract

The incidence of postoperative nausea and vomiting (PONV) is 50% to 80% after neurosurgery. The common prophylactic treatment for postoperative nausea and vomiting is a triple therapy of droperidol, promethazine and dexamethasone. Newer, more effectives methods of prophylaxis are being investigated. We designed this prospective, double-blind, single-center study to compare the efficacy of ondansetron, a neurokinin-1 antagonist, and aprepitant, as a substitute for droperidol, in the prophylactic treatment of postoperative nausea and vomiting after neurosurgery.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Other 7 21%
Student > Master 6 18%
Student > Postgraduate 5 15%
Student > Doctoral Student 3 9%
Researcher 3 9%
Other 6 18%
Unknown 4 12%
Readers by discipline Count As %
Medicine and Dentistry 18 53%
Pharmacology, Toxicology and Pharmaceutical Science 4 12%
Biochemistry, Genetics and Molecular Biology 2 6%
Nursing and Health Professions 1 3%
Psychology 1 3%
Other 1 3%
Unknown 7 21%