Title |
The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes
|
---|---|
Published in |
Cardiovascular Diabetology, October 2008
|
DOI | 10.1186/1475-2840-7-29 |
Pubmed ID | |
Authors |
Robbert Meerwaldt, Thera Links, Clark Zeebregts, Rene Tio, Jan-Luuk Hillebrands, Andries Smit |
Abstract |
Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in particular in diabetes. AGE accumulation is a measure of cumulative metabolic and oxidative stress, and may so represent the "metabolic memory". Furthermore, increased AGE accumulation is closely related to the development of cardiovascular complications in diabetes. This review article will focus on the clinical relevance of measuring AGE accumulation in diabetic patients by focusing on AGE formation, AGEs as predictors of long-term complications, and interventions against AGEs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
United Kingdom | 2 | 1% |
Brazil | 1 | <1% |
Netherlands | 1 | <1% |
Hungary | 1 | <1% |
Estonia | 1 | <1% |
El Salvador | 1 | <1% |
Japan | 1 | <1% |
Russia | 1 | <1% |
Other | 0 | 0% |
Unknown | 148 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 29 | 18% |
Student > Ph. D. Student | 25 | 16% |
Student > Master | 24 | 15% |
Student > Bachelor | 11 | 7% |
Student > Doctoral Student | 10 | 6% |
Other | 35 | 22% |
Unknown | 25 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 50 | 31% |
Agricultural and Biological Sciences | 26 | 16% |
Biochemistry, Genetics and Molecular Biology | 12 | 8% |
Engineering | 8 | 5% |
Chemistry | 5 | 3% |
Other | 27 | 17% |
Unknown | 31 | 19% |