Title |
A large scale survey reveals that chromosomal copy-number alterations significantly affect gene modules involved in cancer initiation and progression
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Published in |
BMC Medical Genomics, May 2011
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DOI | 10.1186/1755-8794-4-37 |
Pubmed ID | |
Authors |
Eva Alloza, Fátima Al-Shahrour, Juan C Cigudosa, Joaquín Dopazo |
Abstract |
Recent observations point towards the existence of a large number of neighborhoods composed of functionally-related gene modules that lie together in the genome. This local component in the distribution of the functionality across chromosomes is probably affecting the own chromosomal architecture by limiting the possibilities in which genes can be arranged and distributed across the genome. As a direct consequence of this fact it is therefore presumable that diseases such as cancer, harboring DNA copy number alterations (CNAs), will have a symptomatology strongly dependent on modules of functionally-related genes rather than on a unique "important" gene. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 2 | 8% |
Netherlands | 1 | 4% |
Finland | 1 | 4% |
United Kingdom | 1 | 4% |
Spain | 1 | 4% |
United States | 1 | 4% |
Unknown | 19 | 73% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 31% |
Student > Ph. D. Student | 6 | 23% |
Professor > Associate Professor | 3 | 12% |
Student > Master | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 15% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 38% |
Medicine and Dentistry | 7 | 27% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Computer Science | 3 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 0 | 0% |
Unknown | 2 | 8% |