Title |
The effects of glycemic control on seizures and seizure-induced excitotoxic cell death
|
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Published in |
BMC Neuroscience, August 2012
|
DOI | 10.1186/1471-2202-13-94 |
Pubmed ID | |
Authors |
Paula Elyse Schauwecker |
Abstract |
Epilepsy is the most common neurological disorder after stroke, affecting more than 50 million persons worldwide. Metabolic disturbances are often associated with epileptic seizures, but the pathogenesis of this relationship is poorly understood. It is known that seizures result in altered glucose metabolism, the reduction of intracellular energy metabolites such as ATP, ADP and phosphocreatine and the accumulation of metabolic intermediates, such as lactate and adenosine. In particular, it has been suggested that the duration and extent of glucose dysregulation may be a predictor of the pathological outcome of status. However, little is known about neither the effects of glycemic control on brain metabolism nor the effects of managing systemic glucose concentrations in epilepsy. |
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Geographical breakdown
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Mexico | 1 | 50% |
Italy | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 66 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 11 | 17% |
Student > Master | 8 | 12% |
Student > Ph. D. Student | 8 | 12% |
Researcher | 6 | 9% |
Student > Doctoral Student | 5 | 8% |
Other | 8 | 12% |
Unknown | 20 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 24% |
Agricultural and Biological Sciences | 9 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Neuroscience | 5 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Other | 4 | 6% |
Unknown | 23 | 35% |