Title |
Modeling RNA polymerase interaction in mitochondria of chordates
|
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Published in |
Biology Direct, August 2012
|
DOI | 10.1186/1745-6150-7-26 |
Pubmed ID | |
Authors |
Vassily A Lyubetsky, Oleg A Zverkov, Sergey A Pirogov, Lev I Rubanov, Alexandr V Seliverstov |
Abstract |
In previous work, we introduced a concept, a mathematical model and its computer realization that describe the interaction between bacterial and phage type RNA polymerases, protein factors, DNA and RNA secondary structures during transcription, including transcription initiation and termination. The model accurately reproduces changes of gene transcription level observed in polymerase sigma-subunit knockout and heat shock experiments in plant plastids. The corresponding computer program and a user guide are available at http://lab6.iitp.ru/en/rivals. Here we apply the model to the analysis of transcription and (partially) translation processes in the mitochondria of frog, rat and human. Notably, mitochondria possess only phage-type polymerases. We consider the entire mitochondrial genome so that our model allows RNA polymerases to complete more than one circle on the DNA strand. |
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