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Modeling RNA polymerase interaction in mitochondria of chordates

Overview of attention for article published in Biology Direct, August 2012
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Title
Modeling RNA polymerase interaction in mitochondria of chordates
Published in
Biology Direct, August 2012
DOI 10.1186/1745-6150-7-26
Pubmed ID
Authors

Vassily A Lyubetsky, Oleg A Zverkov, Sergey A Pirogov, Lev I Rubanov, Alexandr V Seliverstov

Abstract

In previous work, we introduced a concept, a mathematical model and its computer realization that describe the interaction between bacterial and phage type RNA polymerases, protein factors, DNA and RNA secondary structures during transcription, including transcription initiation and termination. The model accurately reproduces changes of gene transcription level observed in polymerase sigma-subunit knockout and heat shock experiments in plant plastids. The corresponding computer program and a user guide are available at http://lab6.iitp.ru/en/rivals. Here we apply the model to the analysis of transcription and (partially) translation processes in the mitochondria of frog, rat and human. Notably, mitochondria possess only phage-type polymerases. We consider the entire mitochondrial genome so that our model allows RNA polymerases to complete more than one circle on the DNA strand.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 6%
Canada 1 6%
Unknown 16 89%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 5 28%
Researcher 4 22%
Student > Ph. D. Student 3 17%
Student > Master 1 6%
Unknown 5 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 22%
Medicine and Dentistry 3 17%
Agricultural and Biological Sciences 2 11%
Psychology 2 11%
Chemistry 2 11%
Other 0 0%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2012.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Biology Direct
#487
of 537 outputs
Outputs of similar age
#167,096
of 184,945 outputs
Outputs of similar age from Biology Direct
#10
of 10 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 537 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,945 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
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