Title |
Co-administration of avian influenza virus H5 plasmid DNA with chicken IL-15 and IL-18 enhanced chickens immune responses
|
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Published in |
BMC Veterinary Research, August 2012
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DOI | 10.1186/1746-6148-8-132 |
Pubmed ID | |
Authors |
Kian-Lam Lim, Seyed Davoud Jazayeri, Swee Keong Yeap, Noorjahan Banu Mohamed Alitheen, Mohd Hair Bejo, Aini Ideris, Abdul Rahman Omar |
Abstract |
DNA vaccines offer several advantages over conventional vaccines in the development of effective vaccines against avian influenza virus (AIV). However, one of the limitations of the DNA vaccine in poultry is that it induces poor immune responses. In this study, chicken interleukin (IL) -15 and IL-18 were used as genetic adjuvants to improve the immune responses induced from the H5 DNA vaccination in chickens. The immunogenicity of the recombinant plasmid DNA was analyzed based on the antibody production, T cell responses and cytokine production, following inoculation in 1-day-old (Trial 1) and 14-day-old (Trial 2) specific-pathogen-free chickens. Hence, the purpose of the present study was to explore the role of chicken IL-15 and IL-18 as adjuvants following the vaccination of chickens with the H5 DNA vaccine. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Malaysia | 1 | 2% |
Mexico | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 46 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 27% |
Researcher | 10 | 20% |
Student > Master | 7 | 14% |
Student > Bachelor | 5 | 10% |
Professor | 2 | 4% |
Other | 4 | 8% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 17 | 35% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Medicine and Dentistry | 5 | 10% |
Immunology and Microbiology | 5 | 10% |
Veterinary Science and Veterinary Medicine | 3 | 6% |
Other | 3 | 6% |
Unknown | 9 | 18% |