Title |
Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic dermatitis via generation of CD4+CD25+Foxp3+ T cells
|
---|---|
Published in |
BMC Immunology, August 2012
|
DOI | 10.1186/1471-2172-13-44 |
Pubmed ID | |
Authors |
Sang-Chul Han, Gyeoung-Jin Kang, Yeong-Jong Ko, Hee-Kyoung Kang, Sang-Wook Moon, Yong-Seok Ann, Eun-Sook Yoo |
Abstract |
Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, is regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in the immune response by preventing or suppressing the differentiation, proliferation and function of various immune cells, including CD4+ T cells. Recent studies report that fermentation has a tremendous capacity to transform chemical structures or create new substances, and the omega-3 polyunsaturated fatty acids (n-3 PUFAs) in fish oil can reduce inflammation in allergic patients. The beneficial effects of natural fish oil (NFO) have been described in many diseases, but the mechanism by which fermented fish oil (FFO) modulates the immune system and the allergic response is poorly understood. In this study, we produced FFO and tested its ability to suppress the allergic inflammatory response and to activate CD4+CD25+Foxp3+ Tregs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 75% |
Argentina | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 21% |
Student > Postgraduate | 6 | 14% |
Student > Master | 6 | 14% |
Student > Doctoral Student | 3 | 7% |
Lecturer | 2 | 5% |
Other | 8 | 19% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 24% |
Immunology and Microbiology | 5 | 12% |
Agricultural and Biological Sciences | 5 | 12% |
Nursing and Health Professions | 3 | 7% |
Engineering | 3 | 7% |
Other | 8 | 19% |
Unknown | 8 | 19% |