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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Central sympatholytics prolong survival in experimental sepsis
|
|---|---|
| Published in |
Critical Care, February 2009
|
| DOI | 10.1186/cc7709 |
| Pubmed ID | |
| Authors |
Stefan Hofer, Jochen Steppan, Tanja Wagner, Benjamin Funke, Christoph Lichtenstern, Eike Martin, Bernhard M Graf, Angelika Bierhaus, Markus A Weigand |
| Abstract |
One of the main causes of death in European and US intensive care units is sepsis. It involves a network of pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IL-6. Furthermore, there is an up regulation of transcription factors such as nuclear factor (NF) kappaB. It has previously been shown that clonidine is able to significantly reduce pro-inflammatory cytokines in surgical patients. We therefore hypothesise that the clinically used central alpha-2 agonist clonidine has the ability to improve survival in experimental sepsis by inhibiting the sympathetic tone and consequently inhibiting the pro-inflammatory cytokine release. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 6% |
| United Kingdom | 1 | 2% |
| Italy | 1 | 2% |
| Netherlands | 1 | 2% |
| Unknown | 48 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 15% |
| Other | 6 | 11% |
| Student > Postgraduate | 6 | 11% |
| Professor > Associate Professor | 6 | 11% |
| Student > Ph. D. Student | 5 | 9% |
| Other | 12 | 22% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 67% |
| Nursing and Health Professions | 2 | 4% |
| Mathematics | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 10 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2012.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Critical Care
#5,970
of 6,554 outputs
Outputs of similar age
#174,357
of 186,036 outputs
Outputs of similar age from Critical Care
#28
of 34 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,036 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.