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Activated Vitamin D vs Hemodialysis (n=8151) HR 0.84 lower limb amputation 0.90 hospitalization for infection 0.91 Ischemic stroke 1.01 acute myocardial infarction EVENTS no-dose, dose, high-dose • Amputation: 5.4%, 3.1%, 0.9% • Infection: 50%, 40%, 30% h