Title |
NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
|
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Published in |
BMC Molecular and Cell Biology, February 2010
|
DOI | 10.1186/1472-6769-10-2 |
Pubmed ID | |
Authors |
Charles Evans, Katrina L Bogan, Peng Song, Charles F Burant, Robert T Kennedy, Charles Brenner |
Abstract |
NAD+ is a coenzyme for hydride transfer enzymes and a substrate for sirtuins and other NAD+-dependent ADPribose transfer enzymes. In wild-type Saccharomyces cerevisiae, calorie restriction accomplished by glucose limitation extends replicative lifespan in a manner that depends on Sir2 and the NAD+ salvage enzymes, nicotinic acid phosphoribosyl transferase and nicotinamidase. Though alterations in the NAD+ to nicotinamide ratio and the NAD+ to NADH ratio are anticipated by models to account for the effects of calorie restriction, the nature of a putative change in NAD+ metabolism requires analytical definition and quantification of the key metabolites. |
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Mendeley readers
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