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Transient defects of mitotic spindle geometry and chromosome segregation errors

Overview of attention for article published in Cell Division, August 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)

Mentioned by

twitter
5 tweeters

Citations

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38 Dimensions

Readers on

mendeley
100 Mendeley
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Title
Transient defects of mitotic spindle geometry and chromosome segregation errors
Published in
Cell Division, August 2012
DOI 10.1186/1747-1028-7-19
Pubmed ID
Authors

William T Silkworth, William T Silkworth, Daniela Cimini

Abstract

Assembly of a bipolar mitotic spindle is essential to ensure accurate chromosome segregation and prevent aneuploidy, and severe mitotic spindle defects are typically associated with cell death. Recent studies have shown that mitotic spindles with initial geometric defects can undergo specific rearrangements so the cell can complete mitosis with a bipolar spindle and undergo bipolar chromosome segregation, thus preventing the risk of cell death associated with abnormal spindle structure. Although this may appear as an advantageous strategy, transient defects in spindle geometry may be even more threatening to a cell population or organism than permanent spindle defects. Indeed, transient spindle geometry defects cause high rates of chromosome mis-segregation and aneuploidy. In this review, we summarize our current knowledge on two specific types of transient spindle geometry defects (transient multipolarity and incomplete spindle pole separation) and describe how these mechanisms cause chromosome mis-segregation and aneuploidy. Finally, we discuss how these transient spindle defects may specifically contribute to the chromosomal instability observed in cancer cells.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Spain 1 1%
United Kingdom 1 1%
Portugal 1 1%
Unknown 95 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 33%
Researcher 17 17%
Student > Bachelor 11 11%
Student > Master 9 9%
Student > Doctoral Student 8 8%
Other 8 8%
Unknown 14 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 36%
Biochemistry, Genetics and Molecular Biology 30 30%
Medicine and Dentistry 8 8%
Engineering 3 3%
Physics and Astronomy 2 2%
Other 4 4%
Unknown 17 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2012.
All research outputs
#958,640
of 4,507,072 outputs
Outputs from Cell Division
#11
of 51 outputs
Outputs of similar age
#16,691
of 76,652 outputs
Outputs of similar age from Cell Division
#1
of 1 outputs
Altmetric has tracked 4,507,072 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,652 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them