Title |
Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses
|
---|---|
Published in |
Retrovirology, August 2012
|
DOI | 10.1186/1742-4690-9-64 |
Pubmed ID | |
Authors |
Rami Doueiri, Rajaneesh Anupam, Mamuka Kvaratskhelia, Kari B Green, Michael D Lairmore, Patrick L Green |
Abstract |
Human T lymphotropic virus type-1 (HTLV-1) and type 2 (HTLV-2) are closely related human retroviruses, but have unique disease associations. HTLV-1 is the causative agent of an aggressive T-cell leukemia known as adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other inflammatory diseases. HTLV-2 infection has not been clearly associated with any disease condition. Although both viruses can transform T cells in vitro, the HTLV-1 provirus is mainly detected in CD4+ T cells whereas HTLV-2 is mainly detected in CD8+ T cells of infected individuals. HTLV-1 and HTLV-2 encode accessory proteins p30 and p28, respectively, which share partial amino acid homology and are required for viral persistence in vivo. The goal of this study was to identify host proteins interacting with p30 and p28 in order to understand their role in pathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 44 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 24% |
Researcher | 6 | 13% |
Student > Bachelor | 5 | 11% |
Student > Postgraduate | 4 | 9% |
Student > Master | 4 | 9% |
Other | 9 | 20% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 39% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Medicine and Dentistry | 6 | 13% |
Immunology and Microbiology | 2 | 4% |
Nursing and Health Professions | 1 | 2% |
Other | 4 | 9% |
Unknown | 8 | 17% |