Title |
Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
|
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Published in |
BMC Musculoskeletal Disorders, August 2012
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DOI | 10.1186/1471-2474-13-144 |
Pubmed ID | |
Authors |
Silvia Díaz-Prado, Claudia Cicione, Emma Muiños-López, Tamara Hermida-Gómez, Natividad Oreiro, Carlos Fernández-López, Francisco J Blanco |
Abstract |
Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and is not completely understood. Recent works have demonstrated the importance of microRNAs (miRNAs) in cartilage function. MiRNAs are a class of small noncoding RNAs that regulate gene expression and are involved in different cellular process: apoptosis, proliferation, development, glucose and lipid metabolism. The aim of this study was to identify and characterize the expression profile of miRNAs in normal and OA chondrocytes and to determine their role in the OA. |
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Japan | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Spain | 1 | 1% |
Germany | 1 | 1% |
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Demographic breakdown
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Student > Bachelor | 7 | 7% |
Student > Doctoral Student | 5 | 5% |
Other | 18 | 19% |
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Unknown | 27 | 28% |