Title |
Trial protocol OPPTIMUM– Does progesterone prophylaxis for the prevention of preterm labour improve outcome?
|
---|---|
Published in |
BMC Pregnancy and Childbirth, August 2012
|
DOI | 10.1186/1471-2393-12-79 |
Pubmed ID | |
Authors |
Jane E Norman, Andrew Shennan, Phillip Bennett, Steven Thornton, Stephen Robson, Neil Marlow, John Norrie, Stavros Petrou, Neil Sebire, Tina Lavender, Sonia Whyte |
Abstract |
Preterm birth is a global problem, with a prevalence of 8 to 12% depending on location. Several large trials and systematic reviews have shown progestogens to be effective in preventing or delaying preterm birth in selected high risk women with a singleton pregnancy (including those with a short cervix or previous preterm birth). Although an improvement in short term neonatal outcomes has been shown in some trials these have not consistently been confirmed in meta-analyses. Additionally data on longer term outcomes is limited to a single trial where no difference in outcomes was demonstrated at four years of age of the child, despite those in the "progesterone" group having a lower incidence of preterm birth. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 20% |
United States | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 66 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 13% |
Other | 8 | 12% |
Researcher | 8 | 12% |
Student > Ph. D. Student | 6 | 9% |
Professor > Associate Professor | 4 | 6% |
Other | 21 | 30% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 36 | 52% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Chemistry | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 8 | 12% |
Unknown | 14 | 20% |