Title |
Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer
|
---|---|
Published in |
Journal of Experimental & Clinical Cancer Research, August 2020
|
DOI | 10.1186/s13046-020-01662-3 |
Pubmed ID | |
Authors |
Yue Ning, Hongmei Zheng, Yuting Zhan, Sile Liu, Yang yang, Hongjing Zang, Jiadi Luo, Qiuyuan Wen, Songqing Fan |
Abstract |
Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metastasis, survival and chemo-resistance. During the progression of lung cancer, mucin proteins have involved all of the procession of lung cancer, which is interacted with many receptor tyrosine kinases signal pathways and mediated cell signals for tumor cell growth and survival. Mucins thus have been considerable as the indicator of negative prognosis and desirable therapeutic targets of lung cancers. In this review, we comprehensively analyzed the role of each member of the mucin family in lung cancer by combining open-accessed database analysis and assembling cutting-edge information about these molecules. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 27% |
Student > Bachelor | 6 | 23% |
Researcher | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Other | 1 | 4% |
Other | 2 | 8% |
Unknown | 6 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 38% |
Medicine and Dentistry | 4 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 12% |
Agricultural and Biological Sciences | 1 | 4% |
Decision Sciences | 1 | 4% |
Other | 1 | 4% |
Unknown | 6 | 23% |