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Monogenic forms of systemic lupus erythematosus: new insights into SLE pathogenesis

Overview of attention for article published in Pediatric Rheumatology, August 2012
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1 X user

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105 Mendeley
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Title
Monogenic forms of systemic lupus erythematosus: new insights into SLE pathogenesis
Published in
Pediatric Rheumatology, August 2012
DOI 10.1186/1546-0096-10-21
Pubmed ID
Authors

Alexandre Belot, Rolando Cimaz

Abstract

The pathogenesis of Systemic Lupus Erythematosus (SLE) is complex and remains poorly understood. Infectious triggers, genetic background, immunological abnormalities and environmental factors are all supposed to interact for the disease development. Familial SLE as well as early-onset juvenile SLE studies make it possible to identify monogenic causes of SLE. Identification of these rare inherited conditions is of great interest to understand both SLE pathogenesis and molecular human tolerance mechanisms. Complement deficiencies, genetic overproduction of interferon-α and apoptosis defects are the main situations that can lead to monogenic SLE.Here, we review the different genes involved in monogenic SLE and highlight their importance in SLE pathogenesis.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 <1%
India 1 <1%
Unknown 103 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 18%
Researcher 18 17%
Student > Master 11 10%
Student > Bachelor 10 10%
Student > Postgraduate 9 9%
Other 19 18%
Unknown 19 18%
Readers by discipline Count As %
Medicine and Dentistry 46 44%
Immunology and Microbiology 12 11%
Biochemistry, Genetics and Molecular Biology 12 11%
Agricultural and Biological Sciences 9 9%
Computer Science 2 2%
Other 5 5%
Unknown 19 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2012.
All research outputs
#18,312,024
of 22,673,450 outputs
Outputs from Pediatric Rheumatology
#554
of 690 outputs
Outputs of similar age
#128,523
of 167,363 outputs
Outputs of similar age from Pediatric Rheumatology
#6
of 13 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 690 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,363 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.