Title |
Monogenic forms of systemic lupus erythematosus: new insights into SLE pathogenesis
|
---|---|
Published in |
Pediatric Rheumatology, August 2012
|
DOI | 10.1186/1546-0096-10-21 |
Pubmed ID | |
Authors |
Alexandre Belot, Rolando Cimaz |
Abstract |
The pathogenesis of Systemic Lupus Erythematosus (SLE) is complex and remains poorly understood. Infectious triggers, genetic background, immunological abnormalities and environmental factors are all supposed to interact for the disease development. Familial SLE as well as early-onset juvenile SLE studies make it possible to identify monogenic causes of SLE. Identification of these rare inherited conditions is of great interest to understand both SLE pathogenesis and molecular human tolerance mechanisms. Complement deficiencies, genetic overproduction of interferon-α and apoptosis defects are the main situations that can lead to monogenic SLE.Here, we review the different genes involved in monogenic SLE and highlight their importance in SLE pathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
India | 1 | <1% |
Unknown | 103 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 18% |
Researcher | 18 | 17% |
Student > Master | 11 | 10% |
Student > Bachelor | 10 | 10% |
Student > Postgraduate | 9 | 9% |
Other | 19 | 18% |
Unknown | 19 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 46 | 44% |
Immunology and Microbiology | 12 | 11% |
Biochemistry, Genetics and Molecular Biology | 12 | 11% |
Agricultural and Biological Sciences | 9 | 9% |
Computer Science | 2 | 2% |
Other | 5 | 5% |
Unknown | 19 | 18% |