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Risk and outcome of pyelonephritis among renal transplant recipients

Overview of attention for article published in BMC Infectious Diseases, June 2016
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Title
Risk and outcome of pyelonephritis among renal transplant recipients
Published in
BMC Infectious Diseases, June 2016
DOI 10.1186/s12879-016-1608-x
Pubmed ID
Authors

Mette Elneff Graversen, Lars Skov Dalgaard, Søren Jensen-Fangel, Bente Jespersen, Lars Østergaard, Ole Schmeltz Søgaard

Abstract

Urinary tract infection is the most common infectious disease requiring hospitalisation following renal transplantation. However, the risk and outcome of post-transplant pyelonephritis remains unclear. This population-based cohort study was conducted from 1 January 1990 to 31 December 2009. Each member of a Danish population-based, nationwide cohort of first-time renal transplant recipients was matched by age and gender with up to 19 population controls. Information on hospital discharge diagnosis, emigration, and mortality was obtained from nationwide administrative databases. Individuals were observed from the date of first renal transplantation and until graft loss, emigration, or death. Risk factors were assessed by Poisson regression. The incidence rate (IR) of first-time hospitalisation for pyelonephritis was 18.5 (95 % confidence interval [CI]: 16.4-20.9) per 1,000 person-years of follow-up (PYFU) among renal transplant recipients (N = 2,656) and 0.26 (CI: 0.21-0.31) per 1,000 PYFU among population controls (N = 49,226) yielding an incidence rate-ratio (IRR) of 72.0 (95 % CI: 57.8-89.7). Among renal transplant recipients, the risk of pyelonephritis decreased during the entire study period and was lowest in 2005-09 (IRR = 0.46, CI: 0.31-0.68). The highest risk of pyelonephritis was observed within the first six months post-transplantation (IR = 69.9 per 1,000 PYFU; CI: 56.4-86.7). Other risk factors for post-transplant pyelonephritis included female gender, high Charlson comorbidity index score, HLA-DR mismatch, cause of renal failure, and calendar period. Interestingly, we found that the combined risk of graft loss and death was 45 %, (CI: 19-77 %) higher in renal transplant recipients following post-transplant pyelonephritis compared to those who had no admission due to pyelonephritis. The risk of first-time hospitalisation for pyelonephritis among renal transplant recipients is high. Further, post-transplant pyelonephritis was associated with excess risk of graft loss and death; this indicates that strategies aimed at reducing upper urinary tract infections are likely to enhance renal graft survival.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Other 9 20%
Student > Postgraduate 5 11%
Student > Bachelor 4 9%
Student > Ph. D. Student 4 9%
Researcher 4 9%
Other 10 22%
Unknown 9 20%
Readers by discipline Count As %
Medicine and Dentistry 22 49%
Nursing and Health Professions 3 7%
Social Sciences 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Business, Management and Accounting 1 2%
Other 4 9%
Unknown 11 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2023.
All research outputs
#16,038,652
of 25,365,817 outputs
Outputs from BMC Infectious Diseases
#4,379
of 8,556 outputs
Outputs of similar age
#205,486
of 353,994 outputs
Outputs of similar age from BMC Infectious Diseases
#77
of 169 outputs
Altmetric has tracked 25,365,817 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,556 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,994 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.