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Aquaporin 7 involved in GINSENOSIDE-RB1-mediated anti-obesity via peroxisome proliferator-activated receptor gamma pathway

Overview of attention for article published in Nutrition & Metabolism, August 2020
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Title
Aquaporin 7 involved in GINSENOSIDE-RB1-mediated anti-obesity via peroxisome proliferator-activated receptor gamma pathway
Published in
Nutrition & Metabolism, August 2020
DOI 10.1186/s12986-020-00490-8
Pubmed ID
Authors

Rong Guo, Lei Wang, Xianqin Zeng, Minghao Liu, Peng Zhou, Huixia Lu, Huili Lin, Mei Dong

Abstract

Obesity, characterized by the excessive accumulation of triglycerides in adipocytes and their decreased excretion from adipocytes, is closely related to various health problems. Ginsenoside Rb1 (Rb1), the most active component of the traditional Chinese medicine ginseng, has been reported to have positive effects on lipid metabolism. The aim of the present study was to determine the protective effects of Rb1 on glycolipid metabolism under obesity conditions and its mechanisms and to reveal the signaling pathways involved. In our study, male C57BL/6 mice with obesity induced by a high-fat diet (HFD) and mature 3 T3-L1 adipocytes were used to investigate the role of Rb1 in lipid accumulation and explore its possible molecular mechanism in vivo and in vitro, respectively. Rb1 reduced the body weight, fat mass, adipocytes size and serum free fatty acid (FFA) concentration of obese mice. In differentiated 3 T3-L1 adipocytes, Rb1 reduced the accumulation of lipid droplets and stimulated output of triglycerides. Additionally, the expression of peroxisome proliferator-activated receptor gamma (PPARγ), phosphorylated PPARγ (Ser112) and aquaporin 7 (AQP7) was upregulated in adipocytes and adipose tissues upon Rb1 treatment. However, intervention of GW9662, PPARγ antagonist, attenuated Rb1-mediated effects on glycolipid metabolism and AQP7 levels. These data indicated that Rb1 reduced body weight and improved glycolipid metabolism by upregulating PPARγ and AQP7 protein levels. Our study indicated a potential role for Rb1 in the prevention and treatment of obesity.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 29%
Student > Doctoral Student 1 14%
Student > Bachelor 1 14%
Unknown 3 43%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 14%
Materials Science 1 14%
Neuroscience 1 14%
Medicine and Dentistry 1 14%
Unknown 3 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2020.
All research outputs
#16,551,238
of 18,708,811 outputs
Outputs from Nutrition & Metabolism
#766
of 856 outputs
Outputs of similar age
#259,564
of 307,988 outputs
Outputs of similar age from Nutrition & Metabolism
#1
of 1 outputs
Altmetric has tracked 18,708,811 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 856 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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