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Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice

Overview of attention for article published in Stem Cell Research & Therapy, August 2012
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39 Mendeley
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Title
Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice
Published in
Stem Cell Research & Therapy, August 2012
DOI 10.1186/scrt124
Pubmed ID
Authors

Maik MA Worlitzer, Eva C Bunk, Kathrin Hemmer, Jens C Schwamborn

Abstract

ABSTRACT: INTRODUCTION: The adult mammalian brain retains niches for neural stem cells (NSCs), which can generate glial and neuronal components of the brain tissue. However, it is barely established how chronic neuroinflammation, as it occurs in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, affects adult neurogenesis and, therefore, modulates the brain's potential for self-regeneration. METHODS: Neural stem cell culture techniques, intraventricular tumor necrosis factor (TNF)-α infusion and the 6-hydroxydopamine mouse model were used to investigate the influence of neuroinflammation on adult neurogenesis in the Parkinson's disease background. Microscopic methods and behavioral tests were used to analyze samples. RESULTS: Here, we demonstrate that differences in the chronicity of TNF-α application to cultured NSCs result in opposed effects on their proliferation. However, chronic TNF-α treatment, mimicking Parkinson's disease associated neuroinflammation, shows detrimental effects on neural progenitor cell activity. Inversely, pharmacological inhibition of neuroinflammation in a 6-hydroxydopamine mouse model led to increased neural progenitor cell proliferation in the subventricular zone and neuroblast migration into the lesioned striatum. Four months after surgery, we measured improved Parkinson's disease-associated behavior, which was correlated with long-term anti-inflammatory treatment. But surprisingly, instead of newly generated striatal neurons, oligodendrogenesis in the striatum of treated mice was enhanced. CONCLUSIONS: We conclude that anti-inflammatory treatment, in a 6-hydroxydopamine mouse model for Parkinson's disease, leads to activation of adult neural stem cells. These adult neural stem cells generate striatal oligodendrocytes. The higher numbers of newborn oligodendrocytes possibly contribute to axonal stability and function in this mouse model of Parkinson's disease and thereby attenuate dysfunctions of basalganglian motor-control.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Canada 1 3%
Unknown 36 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 23%
Student > Ph. D. Student 8 21%
Student > Bachelor 7 18%
Researcher 3 8%
Other 2 5%
Other 5 13%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 28%
Medicine and Dentistry 8 21%
Neuroscience 5 13%
Biochemistry, Genetics and Molecular Biology 3 8%
Unspecified 1 3%
Other 5 13%
Unknown 6 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2012.
All research outputs
#12,838,902
of 19,432,554 outputs
Outputs from Stem Cell Research & Therapy
#1,069
of 1,990 outputs
Outputs of similar age
#86,836
of 140,805 outputs
Outputs of similar age from Stem Cell Research & Therapy
#2
of 3 outputs
Altmetric has tracked 19,432,554 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,990 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,805 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.