Title |
Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes
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Published in |
BMC Neuroscience, February 2012
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DOI | 10.1186/1471-2202-13-23 |
Pubmed ID | |
Authors |
Marina Negrão Frota de Almeida, Fabíola de Carvalho Chaves de Siqueira Mendes, André Pinheiro Gurgel Felício, Manoela Falsoni, Márcia Lorena Ferreira de Andrade, João Bento-Torres, Pedro Fernando da Costa Vasconcelos, Victor Hugh Perry, Cristovam Wanderley Picanço-Diniz, Marcia Consentino Kronka Sosthenes |
Abstract |
Chewing imbalances are associated with neurodegeneration and are risk factors for senile dementia in humans and memory deficits in experimental animals. We investigated the impact of long-term reduced mastication on spatial memory in young, mature and aged female albino Swiss mice by stereological analysis of the laminar distribution of CA1 astrocytes. A soft diet (SD) was used to reduce mastication in the experimental group, whereas the control group was fed a hard diet (HD). Assays were performed in 3-, 6- and 18-month-old SD and HD mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Iran, Islamic Republic of | 1 | 2% |
Chile | 1 | 2% |
United States | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 21% |
Student > Master | 8 | 17% |
Student > Ph. D. Student | 6 | 13% |
Student > Bachelor | 5 | 11% |
Professor | 4 | 9% |
Other | 5 | 11% |
Unknown | 9 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 36% |
Neuroscience | 8 | 17% |
Psychology | 6 | 13% |
Agricultural and Biological Sciences | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Other | 3 | 6% |
Unknown | 9 | 19% |