Title |
Protocol for diaphragm pacing in patients with respiratory muscle weakness due to motor neurone disease (DiPALS): a randomised controlled trial
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Published in |
BMC Neurology, August 2012
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DOI | 10.1186/1471-2377-12-74 |
Pubmed ID | |
Authors |
Christopher J McDermott, Chin Maguire, Cindy L Cooper, Roger Ackroyd, Wendy O Baird, Simon Baudouin, Andrew Bentley, Stephen Bianchi, Stephen Bourke, Mike J Bradburn, Simon Dixon, John Ealing, Simon Galloway, Dayalan Karat, Nick Maynard, Karen Morrison, Naveed Mustfa, John Stradling, Kevin Talbot, Tim Williams, Pamela J Shaw |
Abstract |
Motor neurone disease (MND) is a devastating illness which leads to muscle weakness and death, usually within 2-3 years of symptom onset. Respiratory insufficiency is a common cause of morbidity, particularly in later stages of MND and respiratory complications are the leading cause of mortality in MND patients. Non Invasive Ventilation (NIV) is the current standard therapy to manage respiratory insufficiency. Some MND patients however do not tolerate NIV due to a number of issues including mask interface problems and claustrophobia. In those that do tolerate NIV, eventually respiratory muscle weakness will progress to a point at which intermittent/overnight NIV is ineffective. The NeuRx RA/4 Diaphragm Pacing System was originally developed for patients with respiratory insufficiency and diaphragm paralysis secondary to stable high spinal cord injuries. The DiPALS study will assess the effect of diaphragm pacing (DP) when used to treat patients with MND and respiratory insufficiency. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Egypt | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | <1% |
Unknown | 140 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 23 | 16% |
Student > Master | 20 | 14% |
Student > Ph. D. Student | 17 | 12% |
Student > Bachelor | 16 | 11% |
Student > Doctoral Student | 7 | 5% |
Other | 19 | 13% |
Unknown | 39 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 51 | 36% |
Nursing and Health Professions | 8 | 6% |
Social Sciences | 7 | 5% |
Neuroscience | 6 | 4% |
Psychology | 6 | 4% |
Other | 20 | 14% |
Unknown | 43 | 30% |