Title |
Reconstructing DNA copy number by joint segmentation of multiple sequences
|
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Published in |
BMC Bioinformatics, August 2012
|
DOI | 10.1186/1471-2105-13-205 |
Pubmed ID | |
Authors |
Zhongyang Zhang, Kenneth Lange, Chiara Sabatti |
Abstract |
Variations in DNA copy number carry information on the modalities of genome evolution and mis-regulation of DNA replication in cancer cells. Their study can help localize tumor suppressor genes, distinguish different populations of cancerous cells, and identify genomic variations responsible for disease phenotypes. A number of different high throughput technologies can be used to identify copy number variable sites, and the literature documents multiple effective algorithms. We focus here on the specific problem of detecting regions where variation in copy number is relatively common in the sample at hand. This problem encompasses the cases of copy number polymorphisms, related samples, technical replicates, and cancerous sub-populations from the same individual. |
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Geographical breakdown
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Germany | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 6% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 24% |
Student > Ph. D. Student | 8 | 24% |
Student > Master | 4 | 12% |
Other | 3 | 9% |
Student > Doctoral Student | 1 | 3% |
Other | 4 | 12% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 26% |
Computer Science | 7 | 21% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Medicine and Dentistry | 4 | 12% |
Mathematics | 3 | 9% |
Other | 1 | 3% |
Unknown | 6 | 18% |