You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling
|
|---|---|
| Published in |
Journal of Neuroinflammation, August 2012
|
| DOI | 10.1186/1742-2094-9-200 |
| Pubmed ID | |
| Authors |
Michael R Due, Andrew D Piekarz, Natalie Wilson, Polina Feldman, Matthew S Ripsch, Sherry Chavez, Hang Yin, Rajesh Khanna, Fletcher A White |
| Abstract |
Multiple adverse events are associated with the use of morphine for the treatment of chronic non-cancer pain, including opioid-induced hyperalgesia (OIH). Mechanisms of OIH are independent of opioid tolerance and may involve the morphine metabolite morphine-3-glucuronide (M3G). M3G exhibits limited affinity for opioid receptors and no analgesic effect. Previous reports suggest that M3G can act via the Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) heterodimer in the central nervous system to elicit pain. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Belgium | 1 | 1% |
| Unknown | 75 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 23% |
| Researcher | 13 | 17% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 6 | 8% |
| Other | 6 | 8% |
| Other | 11 | 14% |
| Unknown | 17 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 26% |
| Agricultural and Biological Sciences | 11 | 14% |
| Neuroscience | 10 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Engineering | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 19 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2023.
All research outputs
#8,269,042
of 26,017,215 outputs
Outputs from Journal of Neuroinflammation
#1,375
of 2,992 outputs
Outputs of similar age
#56,673
of 178,446 outputs
Outputs of similar age from Journal of Neuroinflammation
#19
of 55 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,992 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,446 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.