Title |
Next-generation sequencing of cervical DNA detects human papillomavirus types not detected by commercial kits
|
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Published in |
Virology Journal, August 2012
|
DOI | 10.1186/1743-422x-9-164 |
Pubmed ID | |
Authors |
Tracy L Meiring, Anna T Salimo, Beatrix Coetzee, Hans J Maree, Jennifer Moodley, Inga I Hitzeroth, Michael-John Freeborough, Ed P Rybicki, Anna-Lise Williamson |
Abstract |
Human papillomavirus (HPV) is the aetiological agent for cervical cancer and genital warts. Concurrent HPV and HIV infection in the South African population is high. HIV positive (+) women are often infected with multiple, rare and undetermined HPV types. Data on HPV incidence and genotype distribution are based on commercial HPV detection kits, but these kits may not detect all HPV types in HIV + women. The objectives of this study were to (i) identify the HPV types not detected by commercial genotyping kits present in a cervical specimen from an HIV positive South African woman using next generation sequencing, and (ii) determine if these types were prevalent in a cohort of HIV-infected South African women. |
X Demographics
Geographical breakdown
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Canada | 1 | 20% |
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Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
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Spain | 1 | <1% |
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South Africa | 1 | <1% |
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Readers by professional status | Count | As % |
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