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Proton nuclear magnetic resonance and pattern recognition analysis of liver extracts from rats under different anesthetics

Overview of attention for article published in BMC Medical Imaging, August 2012
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Title
Proton nuclear magnetic resonance and pattern recognition analysis of liver extracts from rats under different anesthetics
Published in
BMC Medical Imaging, August 2012
DOI 10.1186/1471-2342-12-28
Pubmed ID
Authors

Tomoyuki Tajima, Keiko Hirakawa, Hiroshi Kawaguchi, Atsuhiro Sakamoto

Abstract

Although general anesthesia is widely used in the surgical arena, the mechanisms by which general anesthetics act remain unclear. We previously described alterations in gene expression ratios in hepatic tissue taken from rats treated with anesthetics. Consequently, it is considered that anesthetics influence liver metabolism. Thus, the goal of this study was to use pattern recognition analysis of proton nuclear magnetic resonance spectra to visualize changes in liver metabolic phenotypes in response to widely used intravenous anesthetics (propofol and dexmedetomidine) and inhalational anesthetics (sevoflurane and isoflurane).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 5%
Canada 1 5%
Unknown 19 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Student > Bachelor 3 14%
Student > Master 3 14%
Student > Doctoral Student 2 10%
Professor 2 10%
Other 4 19%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 9 43%
Biochemistry, Genetics and Molecular Biology 4 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Veterinary Science and Veterinary Medicine 1 5%
Nursing and Health Professions 1 5%
Other 3 14%
Unknown 1 5%