Title |
Medulla oblongata transcriptome changes during presymptomatic natural scrapie and their association with prion-related lesions
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Published in |
BMC Genomics, August 2012
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DOI | 10.1186/1471-2164-13-399 |
Pubmed ID | |
Authors |
Hicham Filali, Inmaculada Martin-Burriel, Frank Harders, Luis Varona, Carmen Serrano, Cristina Acín, Juan J Badiola, Alex Bossers, Rosa Bolea |
Abstract |
The pathogenesis of natural scrapie and other prion diseases is still poorly understood. Determining the variations in the transcriptome in the early phases of the disease might clarify some of the molecular mechanisms of the prion-induced pathology and allow for the development of new biomarkers for diagnosis and therapy. This study is the first to focus on the identification of genes regulated during the preclinical phases of natural scrapie in the ovine medulla oblongata (MO) and the association of these genes with prion deposition, astrocytosis and spongiosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 32% |
Student > Ph. D. Student | 6 | 19% |
Student > Bachelor | 3 | 10% |
Professor | 3 | 10% |
Student > Master | 1 | 3% |
Other | 3 | 10% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 29% |
Agricultural and Biological Sciences | 8 | 26% |
Veterinary Science and Veterinary Medicine | 3 | 10% |
Neuroscience | 2 | 6% |
Medicine and Dentistry | 2 | 6% |
Other | 2 | 6% |
Unknown | 5 | 16% |